The domain within your query sequence starts at position 3216 and ends at position 3278; the E-value for the RPT_1 domain shown below is 2.93e-23.

GLGSNQSSQYGQYRCPSSHYSSQSQHGVGCSHGFNTGQYGSGSYPSSNSRQNCPGSGLCP
TSE

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.