The domain within your query sequence starts at position 335 and ends at position 462; the E-value for the RPT_1 domain shown below is 1.55e-9.

KQPSFTEPKMSQEHLERKTSISSMRTSISERLMQESRESKSISQTTRTSFDEDQSSLYKL
LETRFSPIARRRSSLAEDQAFQEVLEPKYRHHSSGKKTSFAEETLFHEHNEQKYDPPNTK
RRSFANDK

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.