The domain within your query sequence starts at position 354 and ends at position 451; the E-value for the RPT_1 domain shown below is 8.38e-14.

RQPVGEPNPLMDSLIQDRQEVIARIAQHLIHCDPSSSRMSELPFNTQESTSLSPKLHPVS
QESGCVRRYKEAFSVSFGSPEFGSPGDSREGKVREKSE

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.