The domain within your query sequence starts at position 394 and ends at position 473; the E-value for the RPT_1 domain shown below is 1.35e-6.

SKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSS
SLQEQLTPSTVTFSEQLTPS

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.