The domain within your query sequence starts at position 406 and ends at position 486; the E-value for the RPT_1 domain shown below is 6.24e-9.

HWYATTLQTLMKYPELLSNTQRVYWIAYGQTLLIHGDGQMFRHILNFLRLGKLFLPSEFK
EWPLFCQEVEEYHIPALSEAL

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.