The domain within your query sequence starts at position 443 and ends at position 563; the E-value for the RPT_1 domain shown below is 4.59e-6.

GMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPP
PGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGP
P

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.