The domain within your query sequence starts at position 446 and ends at position 573; the E-value for the RPT_1 domain shown below is 5.65e-42.

PGGRVHEGSRESVWPQEEAGSTGLDTSSPSDSNSFCRESQPSQVAQPCGVGQEDARTQAD
STGPLELLLLDQLLDEVQKEEHVPAPLDWGRNPGSREHEGSQDSLLPLEEAANSGMDTSI
PSIWPTFC

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.