The domain within your query sequence starts at position 446 and ends at position 626; the E-value for the RPT_1 domain shown below is 7e-25.

GVSQAGEEMEQFGQGVRHTIKQAEKEAEKVAHGVQNGVNQAQKEAEKVAHGVQNGVNQAQ
KEAEKVAHGVQNGVNQAQKEAEKVAHGVQTGVNQAGKETQRVGQGVQTGFNQGQKEAEKV
AHGVQTGVNQAGKETQKAGQGVNYAAGQAEKEAEKLGQGVHHAAGQEMNRLQQDVHNGVN
Q

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.