The domain within your query sequence starts at position 446 and ends at position 651; the E-value for the RPT_1 domain shown below is 1.31e-14.

SAVVLINRALEAGDVCAFWDNLVNPATGLAQVEEENAQRYFDALVKVQQFQGTHRGILSW
NDLQAAVSQVNEQVQEETDQVLAISLINEALDQGCPEKTLSALLLPAAGLEDVSLHVAPR
YHLLLVAAKRQKARVTGDPGAVLWLEEIRQGVARANEDTSTAQRIALGVAAINQAIKEGK
AAQTERVLRNPNVALRGIVPDCAKSY

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.