The domain within your query sequence starts at position 456 and ends at position 597; the E-value for the RPT_1 domain shown below is 1.76e-26.

HEIIREDQETLDNIPGNHNTLIISPWEYRCTDLESEHSEERTHHAFCKAEPEQYKDPCLE
WVPITRSPSQGQLRSKDRQDGPIRKNFNKMEAYTSTSNACMMSSGPEFGSGQLYNSLGYS
RNFLQREPLMTTSRPQTFENSL

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.