The domain within your query sequence starts at position 492 and ends at position 549; the E-value for the RPT_1 domain shown below is 3.16e-7.

GYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCE

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.