The domain within your query sequence starts at position 1257 and ends at position 1348; the E-value for the RPT_2 domain shown below is 3.25e-18.

GARGPPGFKGHTGDPGPPGLRGEPGIAGPSGRDGSPGKDGDTGPAGPQGPRGTRGPPGSS
GSPGSPGDPGRPGALGQKGNKGESGSPGLPGF

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.