The domain within your query sequence starts at position 224 and ends at position 281; the E-value for the RPT_2 domain shown below is 1.46e-11.

NILSLANINGSVLTMGSVLTTGSVLTIGSVLTTGSVLTMGSVLTTGSVLTAGSVLTMG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.