The domain within your query sequence starts at position 224 and ends at position 319; the E-value for the RPT_2 domain shown below is 3.18e-5.

DFRDKDGTQVDFRGRGSATTDLDFRNRDTPHSDFRGRHRTRTYQDFRGREVGPCMEFKDR
EMPPMDPKVLDYIQPSPQEREHSGMNMNKREESIHD

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.