The domain within your query sequence starts at position 249 and ends at position 294; the E-value for the RPT_2 domain shown below is 2.8e-5.

GAPGTPGMDGQKGEPGSPGAAGQSGLPGPKGEPGKEGEKGDAGENG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.