The domain within your query sequence starts at position 267 and ends at position 344; the E-value for the RPT_2 domain shown below is 1.27e-8.

VQVCQEATQLAPVKVREAATQPASGKVREAATQLAPVKVRKAATQLAPVKVHEAATQPAP
GKVSDAATQSASVQESGR

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.