The domain within your query sequence starts at position 298 and ends at position 380; the E-value for the RPT_2 domain shown below is 1.4e-5.

QWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKVIYQSLEGAVQA
GQLKIPPGYHPLDVEKEWGKLHV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.