The domain within your query sequence starts at position 488 and ends at position 606; the E-value for the RPT_2 domain shown below is 4.87e-8.

EGEPPRAQEGEETAYQEIKDKGITIQNGPSVPDLNGTTYAETKANGMELQAGGSKGVWNT
EAGVSEAAPIEPEAAGSEATGKDRLAAKEMDTSATMAEALNVKALGDNAESEPVAAEDT

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.