The domain within your query sequence starts at position 165 and ends at position 247; the E-value for the RPT_3 domain shown below is 2.21e-6.

LNEFQNALKIFSKVKSGRVATTDVAAVLESMDISVNPEMIKDVIQHAYEDNYHTMDIGDI
IFTLDELQRQYEDVSVMDEATSG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.