The domain within your query sequence starts at position 291 and ends at position 348; the E-value for the RPT_6 domain shown below is 5.03e-10.

GEKGIPGFPGPRGEPGSHGPPGFPGFKGIQGAAGEPGLFGFLGPKGDLGDRGYPGPPG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.