Rb C-terminal domain
SMART accession number:SM01369
Description: The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure (PMID:16360038).
Family alignment:
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There are 358 Rb_C domains in 358 proteins in SMART's nrdb database.

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