The domain within your query sequence starts at position 761 and ends at position 920; the E-value for the Rb_C domain shown below is 1.28e-96.

ILQYASTRPPTLSPIPHIPRSPYKFSSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTP
RSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGGNPPKPLKKLRFDIEGADEADG
SKHLPAESKFQQKLAEMTSTRTRMQKQRMNESKDVSNKEE

Rb_C

Rb C-terminal domain
Rb_C
SMART accession number:SM01369
Description: The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure (PMID:16360038).
Interpro abstract (IPR015030):

The RB C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure [(PUBMED:16360038)].

Family alignment:
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There are 1145 Rb_C domains in 1145 proteins in SMART's nrdb database.

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