The domain within your query sequence starts at position 349 and ends at position 492; the E-value for the d1sig__ domain shown below is 6e-3.

FYSENEGEGEEAGGYRLYLKDQRQHMTAFPQEMREEEEEMRKEEDEMEDEEDEDEDEDYE
FEEEDEDDDDEEEEEEEEEEEDKEEEMKNEDSDENKYEEEDEVIVRVLEPEQEQEREEIE
HEHVYVHEHIHAHVHTLAAHHHGL

This is a SCOP domain - please see the SCOP entry of d1sig__ for further annotation