• Links (links to other resources describing this domain)
  • OSTEO

    Osteopontin
    OSTEO
    SMART accession number:SM00017
    Description: Osteopontin is an acidic phosphorylated glycoprotein of about 40 Kd which is abundant in the mineral matrix of bones and which binds tightly to hydroxyapatite [1,2,3]. It is suggested that osteopontin might function as a cell attachment factor and could play a key role in the adhesion of osteoclasts to the mineral matrix of bone
    Interpro abstract (IPR002038): The major event of endochondrial ossification is the proteolytic degradation of calcified cartilage and the extracellular matrix, and their substitution with bone-specific extracellular matrix produced and organised by osteoblasts [(PUBMED:2033080)]. One of the most abundant products of osteoblasts is osteopontin, a glycosylated phosphoprotein with a high acidic amino acid content and one copy of the cell attachment sequence RGD [(PUBMED:2033080)]. It is thought that osteopontin may act as a bridge between osteoblasts and the apatite mineral of the bone [(PUBMED:2033080)]. Osteopontin-K is a kidney protein, similar to osteopontin and probably also involved in cell adhesion [(PUBMED:1414488)].
    GO process:cell adhesion (GO:0007155), ossification (GO:0001503)
    Family alignment:
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    There are 78 OSTEO domains in 78 proteins in SMART's nrdb database.

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