FN3Fibronectin type 3 domain
|SMART accession number:||SM00060|
|Description:||One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.|
|Interpro abstract (IPR003961):|
Fibronectins are multi-domain glycoproteins found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes [(PUBMED:3780752)]. They contain multiple copies of 3 repeat regions (types I, II and III), which bind to a variety of substances including heparin, collagen, DNA, actin, fibrin and fibronectin receptors on cell surfaces. The wide variety of these substances means that fibronectins are involved in a number of important functions: e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis [(PUBMED:3031656)]. The role of fibronectin in cell differentiation is demonstrated by the marked reduction in the expression of its gene when neoplastic transformation occurs. Cell attachment has been found to be mediated by the binding of the tetrapeptide RGDS to integrins on the cell surface [(PUBMED:2466295)], although related sequences can also display cell adhesion activity.
Plasma fibronectin occurs as a dimer of 2 different subunits, linked together by 2 disulphide bonds near the C terminus. The difference in the 2 chains occurs in the type III repeat region and is caused by alternative splicing of the mRNA from one gene [(PUBMED:3780752)]. The observation that, in a given protein, an individual repeat of one of the 3 types (e.g., the first FnIII repeat) shows much less similarity to its subsequent tandem repeats within that protein than to its equivalent repeat between fibronectins from other species, has suggested that the repeating structure of fibronectin arose at an early stage of evolution. It also seems to suggest that the structure is subject to high selective pressure [(PUBMED:6317187)].
The fibronectin type III repeat region is an approximately 100 amino acid domain, different tandem repeats of which contain binding sites for DNA, heparin and the cell surface [(PUBMED:3780752)]. The superfamily of sequences believed to contain FnIII repeats represents 45 different families, the majority of which are involved in cell surface binding in some manner, or are receptor protein tyrosine kinases, or cytokine receptors.
|GO function:||protein binding (GO:0005515)|
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- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing FN3 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FN3 domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing FN3 domain in the selected taxonomic class.
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Leahy DJ, Aukhil I, Erickson HP
- 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.
- Cell. 1996; 84: 155-64
- Display abstract
We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
- Huber AH, Wang YM, Bieber AJ, Bjorkman PJ
- Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A.
- Neuron. 1994; 12: 717-31
- Display abstract
We report the crystal structure of two adjacent fibronectin type III repeats from the Drosophila neural cell adhesion molecule neuroglian. Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. The hydrophobic interdomain interface includes a metal-binding site, presumably involved in stabilizing the relative orientation between domains and predicted by sequence comparision to be present in the vertebrate homolog molecule L1. The neuroglian domains are related by a near perfect 2-fold screw axis along the longest molecular dimension. Using this relationship, a model for arrays of tandem fibronectin type III repeats in neuroglian and other molecules is proposed.
- Potts JR, Campbell ID
- Fibronectin structure and assembly.
- Curr Opin Cell Biol. 1994; 6: 648-55
- Display abstract
Significant progress has been made recently in the determination of the structure and assembly of the important matrix protein fibronectin, a molecule mainly constructed from three modular units denoted Fn1, Fn2 and Fn3. Atomic resolution structures are now available for all three single modules, for Fn1 and Fn3 module pairs, and for the disulphide-linked join between fibronectin monomers. Combined with results from new binding and mutation studies, the new structural information is leading to a clearer view of structure/function relationships in intact fibronectin.
- Skorstengaard K, Holtet TL, Etzerodt M, Thogersen HC
- Collagen-binding recombinant fibronectin fragments containing type II domains.
- FEBS Lett. 1994; 343: 47-50
- Display abstract
Each of the two type II domains and four larger fragments, containing one or two type II domains of fibronectin, have been expressed in Escherichia coli. A special vector, containing a fragment encoding the cleavage site for Factor Xa, Ile-Glu-Gly-Arg, inserted immediately before the protein fragment of interest, was used. After treatment of the purified fusion proteins with reduced/oxidized glutathione, the correctly folded fibronectin fragments were released by proteolytic digestion with Factor Xa. The largest fragment, consisting of two type II and two type I domains, was the only fragment able to bind to immobilized gelatin.
- Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP
- Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
- Science. 1992; 258: 987-91
- Display abstract
Fibronectin type III domains are found in many different proteins including cell surface receptors and cell adhesion molecules. The crystal structure of one such domain from the extracellular matrix protein tenascin was determined. The structure was solved by multiwavelength anomalous diffraction (MAD) phasing of the selenomethionyl protein and has been refined to 1.8 angstrom resolution. The folding topology of this domain is identical to that of the extracellular domains of the human growth hormone receptor, the second domain of CD4, and PapD. Although distinct, this topology is similar to that of immunoglobulin constant domains. An Arg-Gly-Asp (RGD) sequence that can function for cell adhesion is found in a tight turn on an exposed loop.
- Main AL, Harvey TS, Baron M, Boyd J, Campbell ID
- The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions.
- Cell. 1992; 71: 671-8
- Display abstract
The solution structure of the tenth type III module of fibronectin has been determined using nuclear magnetic resonance techniques. The molecule has a fold similar to that of immunoglobulin domains, with seven beta strands forming two antiparallel beta sheets, which pack against each other. Both beta sheets contribute conserved hydrophobic residues to a compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor than to that of immunoglobulin C domains. The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion. This tripeptide is solvent exposed and lies on a conformationally mobile loop between strands F and G, consistent with its cell adhesion function.
- Petersen TE et al.
- Partial primary structure of bovine plasma fibronectin: three types of internal homology.
- Proc Natl Acad Sci U S A. 1983; 80: 137-41
- Balian G, Click EM, Bornstein P
- Location of a collagen-binding domain in fibronectin.
- J Biol Chem. 1980; 255: 3234-6
- Display abstract
Preferential labeling of COOH-terminal sequences in newly synthesized fibronectin was achieved by short term incorporation of radiolabeled amino acids in the presence of pactamycin, an inhibitor of polypeptide chain initiation. The labeled fibronectin was then cleaved with cathepsin D under conditions that yield a large (137,000-dalton) fragment that lacks collagen-binding properties, and a smaller (72,000-dalton) fragment that retains the ability of fibronectin to bind to collagen. Determination of the relative specific radioactivities of the two fragments leads us to conclude that the collagen-binding domain in fibronectin is located in the NH2-terminal third of the polypeptide chain and not in a COOH-terminal region as previously indicated by other structural studies.
- Disease (disease genes where sequence variants are found in this domain)
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the FN3 domain.
Protein Disease Anosmin-1 (P23352) (SMART) OMIM:308700: Kallmann syndrome Leptin receptor (P48357) (SMART) OMIM:601007: LEPTIN RECEPTOR; LEPR Collagen alpha-1(VII) chain (Q02388) (SMART) OMIM:120120: Epidermolysis bullosa dystrophica, dominant
OMIM:131750: Epidermolysis bullosa dystrophica, recessive
OMIM:226600: Epidermolysis bullosa, pretibial, dominant and recessive
Cytokine receptor common subunit gamma (P31785) (SMART) OMIM:308380: Severe combined immunodeficiency, X-linked
OMIM:300400: Combined immunodeficiency, X-linked, moderate
Neural cell adhesion molecule L1 (P32004) (SMART) OMIM:308840: Hydrocephalus due to aqueductal stenosis
OMIM:307000: MASA syndrome
OMIM:303350: Spastic paraplegia
Insulin receptor (P06213) (SMART) OMIM:147670: Leprechaunism
OMIM:246200: Rabson-Mendenhall syndrome
OMIM:262190: Diabetes mellitus, insulin-resistant, with acanthosis nigricans
Integrin beta-4 (P16144) (SMART) OMIM:147557: Epidermolysis bullosa, junctional, with pyloric atresia
OMIM:226730: Epidermolysis bullosa, generalized atrophic benign
- Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath
% proteins involved KEGG pathway ID Description 21.19 map04060 Cytokine-cytokine receptor interaction 13.17 map04360 Axon guidance 8.71 map04514 Cell adhesion molecules (CAMs) 7.56 map04510 Focal adhesion 5.15 map04512 ECM-receptor interaction 5.15 map04640 Hematopoietic cell lineage 4.81 map04520 Adherens junction 3.21 map04810 Regulation of actin cytoskeleton 2.75 map00530 Aminosugars metabolism 2.63 map04080 Neuroactive ligand-receptor interaction 1.72 map05210 Colorectal cancer 1.72 map04650 Natural killer cell mediated cytotoxicity 1.60 map04910 Insulin signaling pathway 1.60 map05215 Prostate cancer 1.15 map05214 Glioma 1.15 map04620 Toll-like receptor signaling pathway 1.15 map04730 Long-term depression 1.15 map05218 Melanoma 1.15 map04914 Progesterone-mediated oocyte maturation 1.03 map04920 Adipocytokine signaling pathway 1.03 map04020 Calcium signaling pathway 0.92 map05222 Small cell lung cancer 0.92 map05120 Epithelial cell signaling in Helicobacter pylori infection 0.92 map05050 Dentatorubropallidoluysian atrophy (DRPLA) 0.92 map04210 Apoptosis 0.92 map04930 Type II diabetes mellitus 0.80 map04120 Ubiquitin mediated proteolysis 0.80 map04660 T cell receptor signaling pathway 0.57 map00500 Starch and sucrose metabolism 0.46 map00361 gamma-Hexachlorocyclohexane degradation 0.34 map04740 Olfactory transduction 0.34 map00790 Folate biosynthesis 0.34 map02020 Two-component system - General 0.34 map00511 N-Glycan degradation 0.34 map01032 Glycan structures - degradation 0.23 map00531 Glycosaminoglycan degradation 0.23 map04010 MAPK signaling pathway 0.23 map04940 Type I diabetes mellitus 0.23 map00604 Glycosphingolipid biosynthesis - ganglioseries 0.23 map00600 Sphingolipid metabolism 0.11 map00603 Glycosphingolipid biosynthesis - globoseries 0.11 map00780 Biotin metabolism 0.11 map00740 Riboflavin metabolism 0.11 map00300 Lysine biosynthesis 0.11 map00310 Lysine degradation 0.11 map00561 Glycerolipid metabolism 0.11 map00052 Galactose metabolism 0.11 map02010 ABC transporters - General 0.11 map00520 Nucleotide sugars metabolism 0.11 map00550 Peptidoglycan biosynthesis
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with FN3 domain which could be assigned to a KEGG orthologous group, and not all proteins containing FN3 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of FN3 domains in PDB
PDB code Main view Title 1a22 HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR 1axi STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE 1bj8 THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE 1bp3 THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX 1bpv TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES 1bqu CYTOKYNE-BINDING REGION OF GP130 1c8p NMR STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE COMMON BETA-CHAIN IN THE GM-CSF, IL-3 AND IL-5 RECEPTORS 1cfb CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS 1cn4 ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR 1eba COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN INACTIVE PEPTIDE [EMP33] CONTAINS 3,5-DIBROMOTYROSINE IN POSITION 4 (DENOTED DBY) 1ebp COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1] 1eer CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS 1egj DOMAIN 4 OF THE BETA COMMON CHAIN IN COMPLEX WITH AN ANTIBODY 1ern NATIVE STRUCTURE OF THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] 1f6f CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR 1fna CRYSTAL STRUCTURE OF THE TENTH TYPE III CELL ADHESION MODULE OF HUMAN FIBRONECTIN 1fnf FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10 1fnh CRYSTAL STRUCTURE OF HEPARIN AND INTEGRIN BINDING SEGMENT OF HUMAN FIBRONECTIN 1gh7 CRYSTAL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE BETA-COMMON RECEPTOR OF IL-3, IL-5, AND GM-CSF 1hwg 1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN 1hwh 1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN 1i1r CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX 1iar INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX 1j8k NMR STRUCTURE OF THE FIBRONECTIN EDA DOMAIN, NMR, 20 STRUCTURES 1k85 Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 Chitinase A1. 1kf9 PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR 1lwr Solution structure of the NCAM fibronectin type III module 2 1mfn SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 20 STRUCTURES 1n26 Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain 1oww Solution structure of the first type III module of human fibronectin determined by 1H, 15N NMR spectroscopy 1p9m Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex 1pvh Crystal structure of leukemia inhibitory factor in complex with gp130 1qg3 CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4 1qr4 TWO FIBRONECTIN TYPE-III DOMAIN SEGMENT FROM CHICKEN TENASCIN 1tdq Structural basis for the interactions between tenascins and the C-type lectin domains from lecticans: evidence for a cross-linking role for tenascins 1ten STRUCTURE OF A FIBRONECTIN TYPE III DOMAIN FROM TENASCIN PHASED BY MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN 1ttf THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS 1ttg THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS 1uc6 Solution Structure of the Carboxyl Terminal Domain of the Ciliary Neurotrophic Factor Receptor 1uem Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein 1uen Solution Structure of The Third Fibronectin III Domain of Human KIAA0343 Protein 1uey Solution Structure of The First Fibronectin Type III Domain of Human KIAA0343 protein 1ujt Solution structure of the second fibronectin Type III domain of human KIAA1568 protein 1v5j Solution Structure of RSGI RUH-008, fn3 domain in Human cDNA 1va9 Solution structure of the second FNIII domain of DSCAML1 protein 1wf5 Solution structure of the first Fn3 domain of Sidekick-2 protein 1wfn The fourth FN3 domain of human sidekick-2 1wfo The eighth FN3 domain of human sidekick-2 1wft Solution structure of C-terminal fibronectin type III domain of mouse 1700129L13Rik protein 1wfu Solution structure of fibronectin type III domain of mouse hypothetical protein 1wis Solution structure of the fifth FNIII domain from human KIAA1514 protein 1wj3 Solution structure of the fourth fn3 domain of KIAA1496 protein 1wk0 Solution structure of Fibronectin type III domain derived from human KIAA0970 protein 1x3d Solution structure of the fibronectin type-III domain of human fibronectin type-III domain containing protein 3a 1x4x Solution structure of the 6th fibronectin type III domain from human fibronectin type III domain containing protein 3 1x4y Solution structure of the 3rd fibronectin type III domain from mouse biregional cell adhesion molecule-related/down-regulated oncogenes (Cdon) binding protein 1x4z Solution structure of the 2nd fibronectin type III domain from mouse biregional cell adhesion molecule-related/down-regulated oncogenes (Cdon) binding protein 1x5a The solution structure of the second fibronectin type III domain of mouse Ephrin type-A receptor 1 1x5f The solution structure of the first fibronectin type III domain of human Neogenin 1x5g The solution structure of the second fibronectin type III domain of human Neogenin 1x5h The solution structure of the third fibronectin type III domain of human Neogenin 1x5i The solution structure of the fourth fibronectin type III domain of human Neogenin 1x5j The solution structure of the fifth fibronectin type III domain of human Neogenin 1x5k The solution structure of the sixth fibronectin type III domain of human Neogenin 1x5l Solution structure of the second fn3 domain of Eph receptor A8 protein 1x5x Solution structure of the fibronectin type-III domain of human fibronectin type III domain containing protein 3 1x5y Solution structure of the fibronectin type-III domain of mouse myosin-binding protein C, Fast-type homolog 1x5z Solution structure of the fibronectin type-III domain of human protein tyrosine phosphatase, receptor type, D isoform 4 variant 1zlg Solution structure of the extracellular matrix protein anosmin-1 2aew A model for growth hormone receptor activation based on subunit rotation within a receptor dimer 2arw The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor 2b5i cytokine receptor complex 2ck2 Structure of core-swapped mutant of fibronectin 2crm Solution structure of the forth FNIII domain of human 2crz Solution structure of the fifth FNIII domain of human fibronectin type III domain containing protein 3a 2csp Solution structure of the FNIII domain of human RIM-binding protein 2 2cuh Solution structure of the 31st fibronectin type III domain of the human tenascin X 2cui Solution structure of the 31st fibronectin type III domain of the human tenascin X 2cum The solution structure of the 33rd fibronectin type III domain of human Tenascin-X 2d9q Crystal Structure of the Human GCSF-Receptor Signaling Complex 2db8 Solution structures of the fn3 domain of human Tripartite motif protein 9 2dbj Solution structures of the fn3 domain of human Proto-oncogene tyrosine-protein kinase MER precursor 2djs Solution structures of the fn3 domain of human ephrin type-B receptor 1 2dju Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F 2dkm Solution structures of the fn3 domain of human collagen alpha-1(XX) chain 2dle Solution structure of the fourth fn3 domain of human receptor-type tyrosine-protein phosphatase eta 2dlh Solution structure of the second fn3 domain of human receptor-type tyrosine-protein phosphatase delta 2dm4 Solution structure of the second fn3 domain of human sorLA/LR11 2dmk The solution structure of the FN3 domain of human Midline 2 protein 2dn7 Solution structures of the 6th fn3 domain of human receptor-type tyrosine-protein phosphatase F 2doc Solution structure of the Fibronectin type-III domain of human Neural cell adhesion molecule 2 2dtg Insulin receptor (IR) ectodomain in complex with fab's 2e3v Crystal structure of the first fibronectin type III domain of neural cell adhesion molecule splicing isoform from human muscle culture lambda-4.4 2e7h Solution structure of the second fn3 domain from human Ephrin type-B receptor 4 2ed7 Solution structure of the first fibronectin type III domain of human Netrin receptor DCC 2ed8 Solution structure of the second fibronectin type III domain of human Netrin receptor DCC 2ed9 Solution structure of the third fibronectin type III domain of human Netrin receptor DCC 2edb Solution structure of the fourth fibronectin type III domain of human Netrin receptor DCC 2edd Solution structure of the fifth fibronectin type III domain of human Netrin receptor DCC 2ede Solution structure of the sixth fibronectin type III domain of human Netrin receptor DCC 2edx Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F 2edy Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F 2ee2 Solution structures of the fn3 domain of human contactin 1 2ee3 Solution structures of the fn3 domain of human collagen alpha-1(XX) chain 2ekj Solution structures of the fn3 domain of human collagen alpha-1(XX) chain 2erj Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 2fnb NMR STRUCTURE OF THE FIBRONECTIN ED-B DOMAIN, NMR, 20 STRUCTURES 2gee Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8 2gys 2.7 A structure of the extracellular domains of the human beta common receptor involved in IL-3, IL-5, and GM-CSF signalling 2h41 Solution structure of the second type III domain of human Fibronectin: minimized average structure 2h45 Solution structure of the second type III domain of human Fibronectin: ensemble of 25 structures 2ha1 Complex of the first and second type III domains of human Fibronectin in solution 2haz Crystal structure of the first fibronectin domain of human NCAM1 2ibb Crystal Structure of the First and Second FNIII Domains of Ihog 2ibg Crystal Structure of Hedgehog Bound to the FNIII Domains of Ihog 2ic2 Crystal Structure of the First FNIII Domain of Ihog 2jix Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor 2jll Crystal structure of NCAM2 IgIV-FN3II 2kbg Solution structure of the second Fibronectin type-III module of NCAM2 2lfg Solution structure of the human prolactin receptor ecd domain d2 2m26 NMR structure of the C-terminal domain of the protein HCFC1 from Mus musculus 2mfn SOLUTION NMR STRUCTURE OF LINKED CELL ATTACHMENT MODULES OF MOUSE FIBRONECTIN CONTAINING THE RGD AND SYNERGY REGIONS, 10 STRUCTURES 2nzi Crystal structure of domains A168-A170 from titin 2obg Crystal Structure of Monobody MBP-74/Maltose Binding Protein Fusion Complex 2ocf Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody 2q7n Crystal structure of Leukemia inhibitory factor in complex with LIF receptor (domains 1-5) 2qbw The crystal structure of PDZ-Fibronectin fusion protein 2rb8 High resolution design of a protein loop 2rbl High resolution design of a protein loop 2uve Structure of Yersinia enterocolitica Family 28 Exopolygalacturonase 2uvf Structure of Yersinia enterocolitica Family 28 Exopolygalacturonase in Complex with Digalaturonic Acid 2v5y Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 2vkw Human NCAM, FN3 domains 1 and 2 2vkx Human NCAM, FN3 domains 1 and 2, M610R mutant 2vtc The structure of a glycoside hydrolase family 61 member, Cel61B from the Hypocrea jecorina. 2w1n cohesin and fibronectin type-III double module construct from the Clostridium perfringens glycoside hydrolase GH84C 2x10 Crystal structure of the complete EphA2 ectodomain 2x11 Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain 2xyc CRYSTAL STRUCTURE OF NCAM2 IGIV-FN3I 2yrz Solution structure of the fibronectin type III domain of human Integrin beta-4 2yuw Solution Structure of 2nd Fibronectin Domain of Slow Type Myosin-Binding Protein C 2yux Solution Structure of 3rd Fibronectin type three Domain of slow type Myosin-Binding Protein C 3b83 Computer-Based Redesign of a beta Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo beta Sheet Design. 3bpl Crystal structure of the IL4-IL4R-Common Gamma ternary complex 3bpn Crystal structure of the IL4-IL4R-IL13Ra ternary complex 3bpo Crystal structure of the IL13-IL4R-IL13Ra ternary complex 3ch8 The crystal structure of PDZ-Fibronectin fusion protein 3csb Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex 3csg Crystal Structure of Monobody YS1(MBP-74)/Maltose Binding Protein Fusion Complex 3cxe Structure of the GM-CSF Receptor Complex 3d1m Crystal Structure of Sonic Hedgehog Bound to the third FNIII domain of CDO 3d48 Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor 3e0g Structure of the Leukemia Inhibitory Factor Receptor (LIF-R) domains D1-D5 3ew3 the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor 3f7p Crystal structure of a complex between integrin beta4 and plectin 3f7q First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4 3f7r First pair of Fibronectin type III domains and part of the connecting segment of the integrin beta4 3fl7 Crystal structure of the human ephrin A2 ectodomain 3hhr HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX 3k2m Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex 3l5h Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly of receptor complexes 3l5i Crystal structure of FnIII domains of human GP130 (Domains 4-6) 3l5j Crystal structure of FnIII domains of human GP130 (Domains 4-6) 3loh Structure of the insulin receptor ectodomain, including ct peptide 3lpw Crystal structure of the FnIII-tandem A77-A78 from the A-band of titin 3lqm Structure of the IL-10R2 Common Chain 3mpc The crystal structure of a Fn3-like protein from Clostridium thermocellum 3mtr Crystal structure of the Ig5-FN1 tandem of human NCAM 3mx0 Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 3mzg Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor 3n06 A mutant human Prolactin receptor antagonist H27A in complex with the extracellular domain of the human prolactin receptor 3n0p A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor 3n1f Crystal Structure of IhhN bound to CDOFn3 3n1g Crystal structure of DhhN bound to BOCFn3 3n1m Crystal Structure of IhhN bound to BOCFn3 3n1p Crystal Structure of IhhN bound to BOCFn3 3n1q Crystal Structure of DhhN bound to CDOFn3 3ncb A mutant human Prolactin receptor antagonist H180A in complex with the extracellular domain of the human prolactin receptor 3ncc A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor 3nce A mutant human Prolactin receptor antagonist H27A in complex with the mutant extracellular domain H188A of the human prolactin receptor 3ncf A mutant human Prolactin receptor antagonist H30A in complex with the mutant extracellular domain H188A of the human prolactin receptor 3npz Prolactin Receptor (PRLR) Complexed with the Natural Hormone (PRL) 3p4l Crystal structure of a hemojuvelin-binding fragment of neogenin 3qaz IL-2 mutant D10 ternary complex 3qb7 Interleukin-4 mutant RGA bound to cytokine receptor common gamma 3qht Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO 3qwq Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin 3qwr Crystal structure of IL-23 in complex with an adnectin 3r8q Structure of Fibronectin domain 12-14 3rzw Crystal Structure of the Monobody ySMB-9 bound to human SUMO1 3s98 human IFNAR1 3se3 human IFNa2-IFNAR ternary complex 3se4 human IFNw-IFNAR ternary complex 3t04 Crystal structure of monobody 7c12/abl1 sh2 domain complex 3t1w Structure of the four-domain fragment Fn7B89 of oncofetal fibronectin 3tes Crystal Structure of Tencon 3teu Crystal structure of fibcon 3tgx IL-21:IL21R complex 3uto Twitchin kinase region from C.elegans (Fn31-NL-kin-CRD-Ig26) 3uyo Crystal structure of monobody SH13/ABL1 SH2 domain complex 3wcy Murine Ifnar1 in complex with interferon-beta 4bk4 crystal structure of the human EphA4 ectodomain 4bk5 crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 (amine-methylated sample) 4bka crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 4bkf crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 4bq6 Crystal structure of the RGMB-NEO1 complex form 1 4bq7 Crystal structure of the RGMB-Neo1 complex form 2 4bq8 Crystal structure of the RGMB-NEO1 complex form 3 4bq9 Crystal structure of the FN5 and FN6 domains of NEO1, form 1 4bqb Crystal structure of the FN5 and FN6 domains of NEO1, form 2 4bqc Crystal structure of the FN5 and FN6 domains of NEO1 bound to SOS 4doh IL20/IL201/IL20R2 Ternary Complex 4gh7 Crystal structure of Anticalin N7A in complex with oncofetal fibronectin fragment Fn7B8 4gns Crystal Structure of the Chs5-Chs6 Exomer Cargo Adaptor Complex 4go6 Crystal structure of HCF-1 self-association sequence 1 4gs7 Structure of the Interleukin-15 quaternary complex 4hlj Axon Guidance Receptor 4huk MATE transporter NorM-NG in complex with TPP and monobody 4hul MATE transporter NorM-NG in complex with Cs+ and monobody 4hum MATE transporter NorM-NG in complex with ethidium and monobody 4hun MATE transporter NorM-NG in complex with R6G and monobody 4i18 Crystal structure of human prolactin receptor complexed with Fab fragment 4je4 Crystal Structure of Monobody NSa1/SHP2 N-SH2 Domain Complex 4jeg Crystal Structure of Monobody CS1/SHP2 C-SH2 Domain Complex 4jmg Crystal structure of the synthetic protein in complex with pY peptide 4jmh Crystal structure of synthetic protein in complex with double pY peptide 4k0v Structural basis for angiopoietin-1 mediated signaling initiation 4lpt Crystal structure of monomeric TENCON variant P54CR4-31 4lpu Crystal structure of TENCON variant P40AR2-32R2 4lpv Crystal structure of TENCON variant P41BR3-42 4lpw Crystal structure of TENCON variant A6 4lpx Crystal structure of TENCON variant D4 4lpy Crystal structure of TENCON variant G10 4lsd Myokine structure 4m4p Crystal structure of EPHA4 ectodomain 4m4r Epha4 ectodomain complex with ephrin a5 4m6a N-Terminal beta-Strand Swapping in a Consensus Derived Alternative Scaffold Driven by Stabilizing Hydrophobic Interactions 4mmx Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin 4mmy Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif 4mmz Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin 4n5u Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240] 4n68 Crystal structure of an internal FN3 domain from human Contactin-5 [PSI-NYSGRC-005804] 4nn5 Cytokine receptor complex - Crystal form 1A 4nn6 Cytokine receptor complex - Crystal form 1B 4nn7 Cytokine receptor complex - Crystal form 2
- Links (links to other resources describing this domain)
PFAM fn3 INTERPRO IPR003961 PROSITE FN3_DOMAIN