PBPe

Eukaryotic homologues of bacterial periplasmic substrate binding proteins.
PBPe
SMART accession number:SM00079
Description: Prokaryotic homologues are represented by a separate alignment: PBPb
Interpro abstract (IPR001320): The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are three classes of ionotropic glutamate receptor, namely NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain, transient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission [(PUBMED:10580501)].
GO component:membrane (GO:0016020)
GO function:extracellular-glutamate-gated ion channel activity (GO:0005234), ionotropic glutamate receptor activity (GO:0004970)
Family alignment:
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There are 1087 PBPe domains in 1086 proteins in SMART's nrdb database.

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