C1

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
C1
SMART accession number:SM00109
Description: Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.
Interpro abstract (IPR002219):

Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC) [(PUBMED:1396661)]. Phorbol esters can directly stimulate PKC. The N-terminal region of PKC, known as C1, has been shown [(PUBMED:2500657)] to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.

GO process:intracellular signal transduction (GO:0035556)
Family alignment:
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There are 15380 C1 domains in 11340 proteins in SMART's nrdb database.

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