Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs.
SMART accession number:SM00164
Description: Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.
Interpro abstract (IPR000195): Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, imply that these domains are GTPase activator proteins of Rab-like small GTPases [(PUBMED:11013213)].
Family alignment:
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There are 10517 TBC domains in 10512 proteins in SMART's nrdb database.

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