SEADomain found in sea urchin sperm protein, enterokinase, agrin
|SMART accession number:||SM00200|
|Description:||Proposed function of regulating or binding carbohydrate sidechains.|
|Interpro abstract (IPR000082):||SEA is an extracellular domain associated with O-glycosylation [(PUBMED:7670383)]. Proteins found to contain SEA-modules include, agrin, enterokinase, 63 kDa Strongylocentrotus purpuratus (Purple sea urchin) sperm protein, perlecan (heparan sulphate proteoglycan core, mucin 1 and the cell surface antigen, 114/A10, and two functionally uncharacterised, probably extracellular, Caenorhabditis elegans proteins. Despite the functional diversity of these adhesive proteins, a common denominator seems to be their existence in heavily glycosylated environments. In addition, the better characterised proteins all contain O-glycosidic-linked carbohydrates such as heparan sulphate that contribute considerably to their molecular masses. The common module might regulate or assist binding to neighbouring carbohydrate moieties. |
Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains [(PUBMED:8052624)].
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