Ubiquitin-conjugating enzyme E2, catalytic domain homologues
SMART accession number:SM00212
Description: Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.
Family alignment:
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There are 43578 UBCc domains in 43296 proteins in SMART's nrdb database.

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