fCBD

Fungal-type cellulose-binding domain
fCBD
SMART accession number:SM00236
Description: Small four-cysteine cellulose-binding domain of fungi
Interpro abstract (IPR000254): The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases (EC 3.2.1.4), cellobiohydrolases (EC 3.2.1.91) (exoglucanases), or xylanases (EC 3.2.1.8) [(PUBMED:1886523)]. Structurally, cellulases and xylanases generally consist of a catalytic domain joined to a cellulose-binding domain (CBD) by a short linker sequence rich in proline and/or hydroxy-amino acids. The CBD of a number of fungal cellulases has been shown to consist of 36 amino acid residues, and it is found either at the N-terminal or at the C-terminal extremity of the enzymes. As it is shown in the following schematic representation, there are four conserved cysteines in this type of CBD domain, all involved in disulphide bonds.

+----------------+
| +-----|---------+
| | | |
xxxxxxxCxxxxxxxxxxCxxxxxCxxxxxxxxxCx
GO process:carbohydrate metabolic process (GO:0005975)
GO component:extracellular region (GO:0005576)
GO function:cellulose binding (GO:0030248), hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)
Family alignment:
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There are 1690 fCBD domains in 1512 proteins in SMART's nrdb database.

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