WH2

Wiskott Aldrich syndrome homology region 2

• SMART accession number: SM00246
• Description: Wiskott Aldrich syndrome homology region 2 / actin-binding motif
• Interpro abstract (IPR003124):

  The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain and with the CRIB domain, and the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments (PUBMED:11434350), (PUBMED:11911886).

There are 700 WH2 domains in 520 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Binding / catalysis: actin binding

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
53.12	map04520	Adherens junction
45.31	map04810	Regulation of actin cytoskeleton
1.56	map04320	Dorso-ventral axis formation

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with WH2 domain which could be assigned to a KEGG orthologous group, and not all proteins containing WH2 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of WH2 domains in PDB

PDB code	Title
2a3z	Ternary complex of the wh2 domain of wasp with actin-dnase i
2a40	Ternary complex of the wh2 domain of wave with actin-dnase i
2a41	Ternary complex of the wh2 domain of wip with actin-dnase i
2d1k	Ternary complex of the wh2 domain of mim with actin-dnase i
2vcp

Links (links to other resources describing this domain)

• INTERPRO: IPR003124