FU

Furin-like repeats

• SMART accession number: SM00261
• Interpro abstract (IPR006212):

  The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation [(PUBMED:1936959)].

There are 15066 FU domains in 2356 proteins in SMART's nrdb database.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the FU domain.

Protein	Disease
Insulin receptor subunit beta (P06213) (SMART)	OMIM:147670: Leprechaunism OMIM:246200: Rabson-Mendenhall syndrome OMIM:262190: Diabetes mellitus, insulin-resistant, with acanthosis nigricans

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
8.70	map04520	Adherens junction
7.93	map05215	Prostate cancer
7.16	map04012	ErbB signaling pathway
7.16	map04020	Calcium signaling pathway
6.91	map04510	Focal adhesion
5.12	map05210	Colorectal cancer
5.12	map05214	Glioma
5.12	map05218	Melanoma
4.35	map05219	Bladder cancer
4.35	map05213	Endometrial cancer
4.35	map05212	Pancreatic cancer
4.35	map05223	Non-small cell lung cancer
3.58	map04810	Regulation of actin cytoskeleton
2.56	map05120	Epithelial cell signaling in Helicobacter pylori infection
2.56	map04060	Cytokine-cytokine receptor interaction
2.56	map04010	MAPK signaling pathway
2.56	map04912	GnRH signaling pathway
2.56	map04320	Dorso-ventral axis formation
2.56	map04540	Gap junction
2.56	map04730	Long-term depression
2.56	map04914	Progesterone-mediated oocyte maturation
1.79	map05050	Dentatorubropallidoluysian atrophy (DRPLA)
1.79	map04910	Insulin signaling pathway
1.79	map04930	Type II diabetes mellitus

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with FU domain which could be assigned to a KEGG orthologous group, and not all proteins containing FU domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of FU domains in PDB

PDB code	Title
1igr	Type 1 insulin-like growth factor receptor (domains 1-3)
1ivo	Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.
1m6b	Structure of the her3 (erbb3) extracellular domain
1mox	Crystal structure of human epidermal growth factor receptor (residues 1-501) in complex with tgf-alpha
1n8y	Crystal structure of the extracellular region of rat her2
1n8z	Crystal structure of extracellular domain of human her2 complexed with herceptin fab
1nql	Structure of the extracellular domain of human epidermal growth factor (egf) receptor in an inactive (low ph) complex with egf.
1s78	Insights into erbb signaling from the structure of the erbb2-pertuzumab complex
1yy9	Structure of the extracellular domain of the epidermal growth factor receptor in complex with the fab fragment of cetuximab/erbitux/imc-c225
2a91	Crystal structure of erbb2 domains 1-3
2ahx	Crystal structure of erbb4/her4 extracellular domain
2dtg	Insulin receptor (ir) ectodomain in complex with fab's
2hr7	Insulin receptor (domains 1-3)
3b2u	Crystal structure of isolated domain iii of the extracellular region of the epidermal growth factor receptor in complex with the fab fragment of imc-11f8
3b2v	Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the fab fragment of imc-11f8
3be1	Dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2
3c09	Crystal structure the fab fragment of matuzumab (fab72000) in complex with domain iii of the extracellular region of egfr
3i2t	Crystal structure of the unliganded drosophila epidermal growth factor receptor ectodomain

Links (links to other resources describing this domain)

• PFAM: Furin-like
• INTERPRO: IPR006212