PUA

Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
PUA
SMART accession number:SM00359
Description: -
Interpro abstract (IPR002478):

The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found [(PUBMED:10093218)]. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [(PUBMED:16793063), (PUBMED:16407303)]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA [(PUBMED:17803682)]. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases [(PUBMED:16943774)].

GO function:RNA binding (GO:0003723)
Family alignment:
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There are 8058 PUA domains in 7970 proteins in SMART's nrdb database.

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