PSI

domain found in Plexins, Semaphorins and Integrins
PSI
SMART accession number:SM00423
Description: -
Interpro abstract (IPR016201):

This entry represents the plexin repeat, which is a disulphide-rich motif with an alpha+beta core structure that contains two conserved disulphides. This repeat motif is found in several different extracellular receptors, including plexins, which are involved in the development of neural and epithelial tissues [(PUBMED:17855350)]; in semaphorins, which regulate axon guidance, immune function and angiogenesis [(PUBMED:12958590)]; in integrins, which are important Metazoan adhesion receptors that transmit conformational change bidirectionally across the membrane (integrin alpha and beta subunits form a head and two long legs in the ectodomain and span the membrane) [(PUBMED:15378069)]; and in hepatocyte growth factor receptor, which plays important roles in normal development and in tumour growth and metastasis [(PUBMED:15167892)].

GO process:multicellular organismal development (GO:0007275)
GO component:membrane (GO:0016020)
GO function:receptor activity (GO:0004872)
Family alignment:
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There are 9978 PSI domains in 6534 proteins in SMART's nrdb database.

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