FGF

Acidic and basic fibroblast growth factor family.
FGF
SMART accession number:SM00442
Description: Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities.
Interpro abstract (IPR002209):

Fibroblast growth factors (FGFs) [(PUBMED:2549857), (PUBMED:3072709)] are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [(PUBMED:1705486), (PUBMED:8760337)]. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [(PUBMED:11276432), (PUBMED:23000357), (PUBMED:15689573), (PUBMED:10441498), (PUBMED:23108135), (PUBMED:23016864)]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [(PUBMED:1649700), (PUBMED:11746231), (PUBMED:14745970), (PUBMED:8978613)]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [(PUBMED:8652550), (PUBMED:11276432)]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [(PUBMED:7583099)], which belong to the tyrosine kinase superfamily.

GO function:growth factor activity (GO:0008083)
Family alignment:
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There are 3105 FGF domains in 2334 proteins in SMART's nrdb database.

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