Small MutS-related domain
SMART accession number:SM00463
Description: -
Interpro abstract (IPR002625):

The Smr domain is an around 90-residue domain found in:

  • The C-terminal region of the mutS2 proteins from bacteria and plants.
  • The small mutS related (smr) proteins from bacteria and eukaryotes.

These proteins could be involved in mismatch repair (MMR) or/and chromosome crossing-over and segregation. It has been proposed that the Smr domain acts as a nicking endonuclease [ (PUBMED:10431172) (PUBMED:10973051) ].

Family alignment:
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There are 8978 SMR domains in 8969 proteins in SMART's nrdb database.

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