DEXDc

DEAD-like helicases superfamily

• SMART accession number: SM00487
• Interpro abstract (IPR014001):

  This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

There are 20719 DEXDc domains in 20551 proteins in SMART's nrdb database.

Disease (disease genes where sequence variants are found in this domain)

SwissProt sequences and OMIM curated human diseases associated with missense mutations within the DEXDc domain.

Protein	Disease
Bloom syndrome protein (SRS)(SMART)	OMIM:210900: Bloom syndrome OMIM:604610: Bloom syndrome OMIM:210900:
DNA excision repair protein ERCC-6 (SRS)(SMART)	OMIM:133540: Cockayne syndrome-2, type B ; Cerebrooculofacioskeletal syndrome OMIM:214150:
Transcriptional regulator ATRX (SRS)(SMART)	OMIM:300032: Alpha-thalassemia/mental retardation syndrome OMIM:301040: Juberg-Marsidi syndrome OMIM:309590: Sutherland-Haan syndrome OMIM:309470: Smith-Fineman-Myers syndrome OMIM:309580:

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
42.61	map00500	Starch and sucrose metabolism
42.61	map00790	Folate biosynthesis
8.48	map00230	Purine metabolism
5.29	map03090	Type II secretion system
0.50	map04310	Wnt signaling pathway
0.20	map03060	Protein export
0.10	map00970	Aminoacyl-tRNA biosynthesis
0.10	map03020	RNA polymerase
0.10	map00330	Arginine and proline metabolism

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with DEXDc domain which could be assigned to a KEGG orthologous group, and not all proteins containing DEXDc domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of DEXDc domains in PDB

PDB code	Title
1a1v	Hepatitis c virus ns3 helicase domain complexed with single stranded sdna
1c4o	Crystal structure of the dna nucleotide excision repair enzyme uvrb from thermus thermophilus
1cu1	Crystal structure of an enzyme complex from hepatitis c virus
1d2m	Uvrb protein of thermus thermophilus hb8; a nucleotide excision repair enzyme
1d9x	Crystal structure of the dna repair protein uvrb
1d9z	Crystal structure of the dna repair protein uvrb in complex with atp
1fuu	Yeast initiation factor 4a
1gku	Reverse gyrase from archaeoglobus fulgidus
1gl9	Archaeoglobus fulgidus reverse gyrase complexed with adpnp
1gm5	Structure of recg bound to three-way dna junction
1hei	Structure of the hepatitis c virus rna helicase domain
1hv8	Crystal structure of a dead box protein from the hyperthermophile methanococcus jannaschii
1oyw	Structure of the recq catalytic core
1oyy	Structure of the recq catalytic core bound to atp-gamma-s
1q0u	Crystal structure of the bstdead n-terminal domain
1qde	Crystal structure of the atpase domain of translation initiation factor 4a from saccharomyces cerevisiae-the prototype of the dead box protein family
1qva	Yeast initiation factor 4a n-terminal domain
1rif	Crystal structure of the uvsw helicase from bacteriophage t4
1s2m	Crystal structure of the dead box protein dhh1p
1t5l	Crystal structure of the dna repair protein uvrb point mutant y96a revealing a novel fold for domain 2
1t6n	Crystal structure of the n-terminal domain of human uap56
1vec	Crystal structure of the n-terminal domain of rck/p54, a human dead-box protein
1wp9	Crystal structure of pyrococcus furiosus hef helicase domain
1wrb	Crystal structure of the n-terminal reca-like domain of djvlgb, a pranarian vasa-like rna helicase
1xti	Structure of wildtype human uap56
1xtj	Structure of human uap56 in complex with adp
1xtk	Structure of decd to dead mutation of human uap56
1yks	Crystal structure of yellow fever virus ns3 helicase
1ymf	Crystal structure of yellow fever virus ns3 helicase complexed with adp
1z3i	Structure of the swi2/snf2 chromatin remodeling domain of eukaryotic rad54
1z63	Sulfolobus solfataricus swi2/snf2 atpase core in complex with dsdna
1z6a	Sulfolobus solfataricus swi2/snf2 atpase core domain
2bhr	Dengue virus rna helicase
2bmf	Dengue virus rna helicase at 2.4a
2d7d	Structural insights into the cryptic dna dependent atp-ase activity of uvrb
2db3	Structural basis for rna unwinding by the dead-box protein drosophila vasa
2eyq	Crystal structure of escherichia coli transcription-repair coupling factor
2f55	Two hepatitis c virus ns3 helicase domains complexed with the same strand of dna
2fdc	Structural basis of dna damage recognition and processing by uvrb: crystal structure of a uvrb/dna complex
2fwr	Structure of archaeoglobus fulgidis xpb
2fz4	Crystal structure of the n-terminal half of archaeoglobus fulgidus xpb
2g9n	Structure of the dead domain of human eukaryotic initiation factor 4a, eif4a
2gxq	Hera n-terminal domain in complex with amp, crystal form 1
2gxs	Hera n-terminal domain in complex with amp, crystal form 2
2gxu	Hera n-terminal domain in complex with orthophosphate, crystal form 1
2hxy	Crystal structure of human apo-eif4aiii
2hyi	Structure of the human exon junction complex with a trapped dead-box helicase bound to rna
2i4i	Crystal structure of human dead-box rna helicase ddx3x
2j0q	The crystal structure of the exon junction complex at 3.2 a resolution
2j0s	The crystal structure of the exon junction complex at 2.2 a resolution
2j0u	The crystal structure of eif4aiii-barentsz complex at 3.0 a resolution
2jlq
2jlr
2jls
2jlu
2jlv
2jlw
2jlx
2jly
2jlz
2kbe
2nmv	Damage detection by the uvrabc pathway: crystal structure of uvrb bound to fluorescein-adducted dna
2oca	The crystal structure of t4 uvsw
2oxc	Human dead-box rna helicase ddx20, dead domain in complex with adp
2p6r	Crystal structure of superfamily 2 helicase hel308 in complex with unwound dna
2p6u	Apo structure of the hel308 superfamily 2 helicase
2pl3	Human dead-box rna helicase ddx10, dead domain in complex with adp
2qeq	Crystal structure of kunjin virus ns3 helicase
2v1x	Crystal structure of human recq-like dna helicase
2v8o	Structure of the murray valley encephalitis virus rna helicase to 1.9a resolution
2va8	Dna repair helicase hel308
2vbc	Crystal structure of the ns3 protease-helicase from dengue virus
2vl7	Structure of s. tokodaii xpd4
2vso	Crystal structure of a translation initiation complex
2vsx	Crystal structure of a translation initiation complex
2w00
2z0m	Crystal structure of hypothetical atp-dependent rna helicase from sulfolobus tokodaii
2z83	Crystal structure of catalytic domain of japanese encephalitis virus ns3 helicase/nucleoside triphosphatase at a resolution 1.8
2zj2
2zj5
2zj8
2zja
2zjo
2zu6
3b6e	Crystal structure of human dech-box rna helicase mda5 (melanoma differentiation-associated protein 5), dech- domain
3b7g	Human dead-box rna helicase ddx20, conserved domain i (dead) in complex with amppnp (adenosine-(beta,gamma)- imidotriphosphate)
3ber	Human dead-box rna-helicase ddx47, conserved domain i in complex with amp
3bor	Crystal structure of the deadc domain of human translation initiation factor 4a-2
3dkp	Human dead-box rna-helicase ddx52, conserved domain i in complex with adp
3dmq
3eiq
3ews
3ex7
3fe2
3fhc
3fho
3fht
3fmo
3fmp
3g0h
3h1t
3i5x
3i5y
3i61
3i62
3iuy
8ohm	Crystal structure of rna helicase from genotype 1b hepatitis c virus: mechanism of unwinding duplex rna

Links (links to other resources describing this domain)

• PFAM: SNF2_N
• INTERPRO: IPR014001
• PROSITE: DEAH_ATP_HELICASE