ChtBD3

Chitin-binding domain type 3

• SMART accession number: SM00495
• Interpro abstract (IPR003610):

  The carbohydrate-binding domain (CBD) is a short domain found in many different glycosyl hydrolase enzymes, such as the C-terminal cellulose-binding domain of endoglucanase Z (PUBMED:9405041). The domain has a core structure consisting of a 3-stranded meander beta-sheet, which contains six aromatic groups that may be important for binding.

  The overall topology of the CBD is structurally similar to the C-terminal chitin-binding domains (ChBD) of chitinase A1 and chitinase B, however the binding mechanism for the ChBD may be different from that of the CBD (PUBMED:10788483).

• GO process: carbohydrate metabolic process (GO:0005975)
• GO component: extracellular region (GO:0005576)
• GO function: carbohydrate binding (GO:0030246), hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)

There are 788 ChtBD3 domains in 499 proteins in SMART's nrdb database.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
90.00	map00530	Aminosugars metabolism
2.00	map00240	Pyrimidine metabolism
2.00	map00500	Starch and sucrose metabolism
2.00	map02040	Flagellar assembly
2.00	map00230	Purine metabolism
2.00	map00760	Nicotinate and nicotinamide metabolism

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with ChtBD3 domain which could be assigned to a KEGG orthologous group, and not all proteins containing ChtBD3 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of ChtBD3 domains in PDB

PDB code	Title
1aiw	Nmr structures of the cellulose-binding domain of the endoglucanase z from erwinia chrysanthemi, 23 structures
1e15	Chitinase b from serratia marcescens
1e6n	Chitinase b from serratia marcescens inactive mutant e144q in complex with n-acetylglucosamine-pentamer
1e6p	Chitinase b from serratia marcescens inactive mutant e144q
1e6r	Chitinase b from serratia marcescens wildtype in complex with inhibitor allosamidin
1e6z	Chitinase b from serratia marcescens wildtype in complex with catalytic intermediate
1ed7	Solution structure of the chitin-binding domain of bacillus circulans wl-12 chitinase a1
1goi	Crystal structure of the d140n mutant of chitinase b from serratia marcescens at 1.45 a resolution
1gpf	Chitinase b from serratia marcescens in complex with inhibitor psammaplin
1h0g	Complex of a chitinase with the natural product cyclopentapeptide argadin from clonostachys
1h0i	Complex of a chitinase with the natural product cyclopentapeptide argifin from gliocladiu
1o6i	Chitinase b from serratia marcescens complexed with the catalytic intermediate mimic cyclic dipeptide ci4.
1ogb	Chitinase b from serratia marcescens mutant d142n
1ogg	Chitinase b from serratia marcescens mutant d142n in complex with inhibitor allosamidin
1ur8	Interactions of a family 18 chitinase with the designed inhibitor hm508, and its degradation product, chitobiono- delta-lactone
1ur9	Interactions of a family 18 chitinase with the designed inhibitor hm508, and its degradation product, chitobiono- delta-lactone
1w1p	Crystal structure of s. marcescens chitinase b in complex with the cyclic dipeptide inhibitor cyclo-(gly-l-pro) at 2.1 a resolution
1w1t	Crystal structure of s. marcescens chitinase b in complex with the cyclic dipeptide inhibitor cyclo-(his-l-pro) at 1.9 a resolution
1w1v	Crystal structure of s. marcescens chitinase b in complex with the cyclic dipeptide inhibitor cyclo-(l-arg-l-pro) at 1.85 a resolution
1w1y	Crystal structure of s. marcescens chitinase b in complex with the cyclic dipeptide inhibitor cyclo-(l-tyr-l-pro) at 1.85 a resolution
1wvu	Crystal structure of chitinase c from streptomyces griseus hut6037
1wvv	Crystal structure of chitinase c mutant e147q
2d49	Solution structure of the chitin-binding domain of streptomyces griseus chitinase c
2dbt	Crystal structure of chitinase c from streptomyces griseus hut6037

Links (links to other resources describing this domain)

• INTERPRO: IPR003610