Syntaxin N-terminal domain
SMART accession number:SM00503
Description: Three-helix domain that (in Sso1p) slows the rate of its reaction with the SNAP-25 homologue Sec9p
Interpro abstract (IPR006011):

Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A ( O35526 ) it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role.

The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors [ (PUBMED:11737951) ].

GO component:membrane (GO:0016020)
Family alignment:
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There are 5994 SynN domains in 5987 proteins in SMART's nrdb database.

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