PolyAC-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein.
|SMART accession number:||SM00517|
|Description:||Involved in homodimerisation (either directly or indirectly)|
|Interpro abstract (IPR002004):|
The polyadenylate-binding protein (PABP) has a conserved C-terminal domain (PABC), which is also found in the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains (IPR000569) [(PUBMED:11287654)]. PABP recognises the 3' mRNA poly(A) tail and plays an essential role in eukaryotic translation initiation and mRNA stabilisation/degradation. PABC domains of PABP are peptide-binding domains that mediate PABP homo-oligomerisation and protein-protein interactions. In mammals, the PABC domain of PABP functions to recruit several different translation factors to the mRNA poly(A) tail [(PUBMED:11940585)].
|GO function:||RNA binding (GO:0003723)|
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- Evolution (species in which this domain is found)
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