domain in high mobilty group proteins HMG14 and HMG 17
SMART accession number:SM00527
Description: -
Interpro abstract (IPR000079): This entry represents the HMGN family, whose members promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates. HMGNs are expressed only in vertebrates [(PUBMED:25281808)].

The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [(PUBMED:25281808)].

GO component:chromatin (GO:0000785), nucleus (GO:0005634)
GO function:nucleosomal DNA binding (GO:0031492)
Family alignment:
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There are 1015 HMG17 domains in 1015 proteins in SMART's nrdb database.

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