SMART: HNS domain annotation

HNS Domain in histone-like proteins of HNS family

SMART accession number:	SM00528
Description:	-
Interpro abstract (IPR027444):	This entry represents the C-terminal domain of the H-NS DNA binding protein. It is composed of an antiparallel beta-sheet, an alpha-helix and a 3 (10)-helix which form a hydrophobic core, stabilising the whole structure. This domain has been found to bind to DNA [ (PUBMED:7875316) ].
GO function:	DNA binding (GO:0003677)
Family alignment:	View or

There are 5250 HNS domains in 4868 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing HNS domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with HNS domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing HNS domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Binding / catalysis: DNA-binding
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Shindo H et al.
- Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from Escherichia coli.
- FEBS Lett. 1995; 360: 125-31
- Display abstract
- The three-dimensional structure of the C-terminal domain (47 residues) obtained from the hydrolysis of H-NS protein with bovine trypsin was determined by NMR measurements and distance geometry calculations. It is composed of an antiparallel beta-sheet, an alpha-helix and a 3(10)-helix which form a hydrophobic core, stabilizing the whole structure. This domain has been found to bind to DNA. Possible DNA binding sites are discussed on the basis of the solution structure of the C-terminal domain of H-NS.
Structure (3D structures containing this domain)

PDB code	Main view	Title
1hnr		H-NS (DNA-BINDING DOMAIN)
1hns		H-NS (DNA-BINDING DOMAIN)
2jr1		Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from the phytopathogen Xylella fastidiosa.
2l92		Solution structure of the C-terminal domain of H-NS like protein Bv3F
2l93		Solution structure of the C-terminal domain of Salmonella H-NS
2lev		Structure of the DNA complex of the C-Terminal domain of Ler
2lrx		RNA structural dynamics are modulated through anti-folding by chaperones

PFAM	Histone_HNS
INTERPRO	IPR027444

HNS