CUE

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs)
CUE
SMART accession number:SM00546
Description: CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)
Interpro abstract (IPR003892):

This domain promotes intramolecular monoubiquitination and has a dual role in mono- and poly-ubiquitination recognition, being involved in binding ubiquitin-conjugating enzymes (UBCs) [ (PUBMED:12573224) (PUBMED:12628920) (PUBMED:23665229) ]. CUE domains also occur in two proteins of the IL-1 signal transduction pathway, tollip and TAB2.

GO function:protein binding (GO:0005515)
Family alignment:
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There are 4656 CUE domains in 4564 proteins in SMART's nrdb database.

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