Ku78

Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen

• SMART accession number: SM00559
• Description: This is a single stranded DNA- and ATP-depedent helicase that has a role in chromosome translocation. This is a domain of unknown function C-terminal to its von Willebrand factor A domain, that also occurs in bacterial hypothetical proteins.
• Interpro abstract (IPR006164):

  The Ku heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 and Ku80 proteins that form a DNA binding heterodimer [ (PUBMED:11493912) ].

• GO process: double-strand break repair via nonhomologous end joining (GO:0006303)
• GO function: DNA binding (GO:0003677)

There are 6431 Ku78 domains in 6429 proteins in SMART's nrdb database.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
50.00	map03030	DNA replication
50.00	map00230	Purine metabolism

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Ku78 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Ku78 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of Ku78 domains in PDB

PDB code	Title
1jeq	Crystal Structure of the Ku Heterodimer
1jey	Crystal Structure of the Ku heterodimer bound to DNA

Links (links to other resources describing this domain)

• INTERPRO: IPR006164