GRAM

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
GRAM
SMART accession number:SM00568
Description:
Interpro abstract (IPR004182):

The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. It is normally about 70 amino acids in length. It is thought to be an intracellular protein-binding or lipid-binding signalling domain, which has an important function in membrane-associated processes. Mutations in the GRAM domain of myotubularins cause a muscle disease, which suggests that the domain is essential for the full function of the enzyme [(PUBMED:11050430)]. Myotubularin-related proteins are a large subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids [(PUBMED:14690594)].

Family alignment:
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There are 1265 GRAM domains in 1057 proteins in SMART's nrdb database.

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