The helicase/SANT-associated (HSA) domain is a predicted DNA-binding domain of ~75 amino acids [ (PUBMED:11779830) ], which is found in the eukaryotic SRCAP/p400/DOM and SNF2/brahma families [ (PUBMED:16024792) ]. While each family has the core sequences that define the HSA domain, they each also have additional sequences that distinguish these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V) is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is found in the SNF2 /brahma family [ (PUBMED:16024792) ]. In addition to the SANT and helicase domains, the HSA domain is also found in association with the bromo domain [ (PUBMED:11779830) ].
Family alignment:
There are 2158 HSA domains in 2154 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing HSA domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with HSA domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing HSA domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Binding / catalysis: DNA-binding
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Systematic identification of novel protein domain families associated with nuclear functions.
Genome Res. 2002; 12: 47-56
Display abstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with HSA domain which could be assigned to a KEGG orthologous group, and not all proteins containing HSA domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
