|SMART accession number:||SM00589|
|Description:||associated with SPRY domains|
|Interpro abstract (IPR006574):|
PRY is a domain associated with SPRY domains. The SPRY domain (IPR003877) is of unknown function however distant homologues are domains in butyrophilin/marenostrin/pyrin. Ca2+-release from the sarcoplasmic or endoplasmic reticulum, the intracellular Ca2+ store, is mediated by the ryanodine receptor (RyR) and/or the inositol trisphosphate receptor (IP3R).
The proteins identified by the PRY domain, clearly fall into 3 sets which can be defined by their combination of signatures:
This set of proteins are described as TRIM (TRIpartite Motif) family members and are involved in cellular compartmentalisation [(PUBMED:11331580)]. The TRIM family sequences are defined by a Ring finger domain, a B-box type1 (B1) and a B-box type 2 (B2) followed by a coiled-coil (CC) region [(PUBMED:1412709)]. Genes belonging to this family are implicated in a variety of processes such as development and cell growth and are involved in human disease.
Many of these proteins, if not all of those with the PRY domain have a number of C-terminal signatures, SPRY, RFP-like (B30.2) and butyrophilin domain. The B30.2-like domain is a well conserved C-terminal domain of 160-170 amino acids which is found in nuclear and cytoplasmic proteins, as well as transmembrane and secreted proteins. The function of the B30.2-like domain is not known, but the cytoplasmic B30.2-like domain of butyrophilin has been shown to interact with xanthine oxidase [(PUBMED:9866204)].
The third set of proteins have the C-terminal signatures but have no N-terminal RING-finger or immunoglobulin domain signatures. These proteins have not been functionally described.
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)