SANT

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

• SMART accession number: SM00717
• Interpro abstract (IPR001005):

  The retroviral oncogene v-myb, and its cellular counterpart c-myb, encode nuclear DNA-binding proteins. In myb, one of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding [(PUBMED:2824190)].

  The SANT domain is present in nuclear receptor co-repressors and in the subunits of many chromatin-remodelling complexes [(PUBMED:8882580)]. It has a strong structural similarity to the DNA-binding domain of Myb-related proteins [(PUBMED:14536084)]. Both consist of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif, each alpha helix containing a bulky aromatic residue. Despite the overall similarity there is differences that indicate that the SANT domain is functionally divergent from the canonical Myb DNA-binding domain [(PUBMED:15040448)].

• GO function: chromatin binding (GO:0003682)

There are 14005 SANT domains in 8878 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Binding / catalysis: DNA-binding

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
25.00	map00500	Starch and sucrose metabolism
25.00	map00790	Folate biosynthesis
15.00	map04330	Notch signaling pathway
12.50	map05050	Dentatorubropallidoluysian atrophy (DRPLA)
12.50	map00230	Purine metabolism
10.00	map05040	Huntington's disease

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with SANT domain which could be assigned to a KEGG orthologous group, and not all proteins containing SANT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of SANT domains in PDB

PDB code	Title
1a5j	Chicken b-myb dna binding domain, repeat 2 and repeat3, nmr, structures
1ba5	Dna-binding domain of human telomeric protein, htrf1, nmr, structures
1guu	Crystal structure of c-myb r1
1gv2	Crystal structure of c-myb r2r3
1gv5	Crystal structure of c-myb r2
1gvd	Crystal structure of c-myb r2 v103l mutant
1h88	Crystal structure of ternary protein-dna complex1
1h89	Crystal structure of ternary protein-dna complex2
1h8a	Crystal structure of ternary protein-dna complex3
1idy	Structure of myb transforming protein, nmr, minimized average structure
1idz	Structure of myb transforming protein, nmr, 20 structures
1ign	Dna-binding domain of rap1 in complex with telomeric dna site
1ity	Solution structure of the dna binding domain of human trf1
1iv6	Solution structure of the dna complex of human trf1
1mbe	Mouse c-myb dna-binding domain repeat 1
1mbf	Mouse c-myb dna-binding domain repeat 1
1mbg	Mouse c-myb dna-binding domain repeat 2
1mbh	Mouse c-myb dna-binding domain repeat 2
1mbj	Mouse c-myb dna-binding domain repeat 3
1mbk	Mouse c-myb dna-binding domain repeat 3
1mse	Solution structure of a specific dna complex of the myb dna- binding domain with cooperative recognition helices
1msf	Solution structure of a specific dna complex of the myb dna- binding domain with cooperative recognition helices
1ofc	Nucleosome recognition module of iswi atpase
1ug2	Solution structure of mouse hypothetical gene (2610100b20rik) product homologous to myb dna-binding domain
1vf9	Solution structure of human trf2
1vfc	Solution structure of the dna complex of human trf2
1w0t	Htrf1 dna-binding domain in complex with telomeric dna.
1w0u	Htrf2 dna-binding domain in complex with telomeric dna.
1wgx	Solution structure of rsgi ruh-022, a myb dna-binding domain in human cdna
1x41	Solution structure of the myb-like dna binding domain of human transcriptional adaptor 2-like, isoform b
1x58	Solution structures of the myb-like dna binding domain of 4930532d21rik protein
1xc5	Solution structure of the smrt deacetylase activation domain
1xg1	Solution structure of myb-domain of human trf2
2aje	Solution structure of the arabidopsis thaliana telomeric repeat-binding protein dna binding domain
2cjj	Crystal structure of the myb domain of the rad transcription factor from antirrhinum majus
2ckx	Crystal structure of ngtrf1, double-stranded telomeric repeat binding factor from nicotiana tabacum.
2cqq	Solution structure of rsgi ruh-037, a myb dna-binding domain in human cdna
2cqr	Solution structure of rsgi ruh-043, a myb dna-binding domain in human cdna
2crg	Solution structure of the myb-like dna-binding domain of mouse mta3 protein
2cu7	Solution structure of the sant domain of human kiaa1915 protein
2d9a	Solution structure of rsgi ruh-050, a myb dna-binding domain in mouse cdna
2dim	Solution structure of the myb_dna-binding domain of human cell division cycle 5-like protein
2din	Solution structure of the myb_dna-binding domain of human cell division cycle 5-like protein
2ebi	Arabidopsis gt-1 dna-binding domain with t133d phosphomimetic mutation
2elk	Solution structure of the sant domain of fission yeast spcc24b10.08c protein
2eqr	Solution structure of the first sant domain from human nuclear receptor corepressor 1
2iw5	Structural basis for corest-dependent demethylation of nucleosomes by the human lsd1 histone demethylase
2jmw	Structure of dna-binding domain of arabidopsis gt-1
2juh	Solution structure of dna binding domain of ngtrf1
2k9n	Solution nmr structure of the r2r3 dna binding domain of myb1 protein from protozoan parasite trichomonas vaginalis
2kdz	Structure of the r2r3 dna binding domain of myb1 protein from protozoan parasite trichomonas vaginalis in complex with mre-1/mre-2r dna
2nog	Sant domain structure of xenopus remodeling factor iswi
2qhb	Crystal structure of ngtrf complexed with telomeric dna
2roh	The dna binding domain of rtbp1
2uxn	Structural basis of histone demethylation by lsd1 revealed by suicide inactivation
2uxx	Human lsd1 histone demethylase-corest in complex with an fad-tranylcypromine adduct
2v1d	Structural basis of lsd1-corest selectivity in histone h3 recognition
2yqk	Solution structure of the sant domain in arginine-glutamic acid dipeptide (re) repeats
2yum	Solution structure of the myb-like dna-binding domain of human zzz3 protein
2yus	Solution structure of the sant domain of human swi/snf- related matrix-associated actin-dependent regulator of chromatin subfamily c member 1
3hm5	Sant domain of human dna methyltransferase 1 associated protein 1

Links (links to other resources describing this domain)

• INTERPRO: IPR001005