SANT

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
SANT
SMART accession number:SM00717
Description:
Interpro abstract (IPR001005):

The retroviral oncogene v-myb, and its cellular counterpart c-myb, encode nuclear DNA-binding proteins. In myb, one of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding [(PUBMED:2824190)].

The SANT domain is present in nuclear receptor co-repressors and in the subunits of many chromatin-remodelling complexes [(PUBMED:8882580)]. It has a strong structural similarity to the DNA-binding domain of Myb-related proteins [(PUBMED:14536084)]. Both consist of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif, each alpha helix containing a bulky aromatic residue. Despite the overall similarity there is differences that indicate that the SANT domain is functionally divergent from the canonical Myb DNA-binding domain [(PUBMED:15040448)].

GO function:chromatin binding (GO:0003682)
Family alignment:
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There are 14005 SANT domains in 8878 proteins in SMART's nrdb database.

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