This domain is found in the transcriptional repressor Sin3. It forms interactions with histone deacetylases [ (PUBMED:12773392) ].
Budding yeast Sin3 is a component of both the Rpd3S and Rpd3L histone deacetylase complexes [ (PUBMED:16314178) ]. In mammals there are two Sin3 paraologues, Sin3A and Sin3B. They forms the larger Sin3L/Rpd3L and the smaller Sin3S/Rpd3S complexes, both complexes rely largely on HDAC (histone deacetylase) activity to affect transcriptional repression. Sin3A and Sin3B may partition into the Sin3L/Rpd3L and Sin3S/Rpd3S complexes, respectively [ (PUBMED:26124119) ].
Family alignment:
There are 2785 HDAC_interact domains in 2783 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing HDAC_interact domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with HDAC_interact domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing HDAC_interact domain in the selected taxonomic class.
Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.
EMBO J. 2003; 22: 2776-87
Display abstract
The post-translational modifications of histones are key to the modulation of chromatin structure. Distinct patterns of modifications established by histone-modifying enzymes control diverse chromosomal processes. Here, we report the purification and molecular characterization of the fission yeast Clr6 histone deacetyl ase involved in higher order chromatin assembly. We show that a chromodomain protein Alp13, which belongs to the conserved MRG protein family linked to cellular senescence in humans, is associated with Clr6. In addition, Clr6 interacts with homologs of the mammalian transcriptional co-repressors Sin3, Pst1 and Pst2, and a WD40 repeat-containing protein, Prw1. Alp13, Pst2 and Prw1 form a stable complex with Clr6 in the nucleus. Deletion of any of these factors causes progressive loss of viability and sensitivity to DNA-damaging agents, and impairs condensation/resolution of chromosomes during mitosis. This is accompanied by hyperacetylation of histones and a reduction in histone H3 Ser10 phosphorylation, which correlates with chromosome condensation during mitosis. These results link the MRG family protein Alp13 to histone deacetylation, and suggest that Clr6 and its associated factors are essential for fundamental chromosomal events.
Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with HDAC_interact domain which could be assigned to a KEGG orthologous group, and not all proteins containing HDAC_interact domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
Links (links to other resources describing this domain)
